What is the difference between inbred and outbred mice

Murray, S. PLoS One 5 , e Article Google Scholar. Tanaka, T. Chalfin, L. Fonio, E. Methods 9 , — Dohm, M. Nevison, C. Tuttle, A. USA , — Miller, R. Prendergast, B. Logan, R. Genes Brain Behav. Mogil, J. NY 46 , — Carter, G. PLoS Genet. Phelan, J. Download references. You can also search for this author in PubMed Google Scholar.

The study was conceived by J. Correspondence to Jeffrey S. Reprints and Permissions. Comparing phenotypic variation between inbred and outbred mice. Nat Methods 15, — Download citation. Published : 30 November Issue Date : December Anyone you share the following link with will be able to read this content:.

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What is Personalized Medicine? Genetics vs. Dec 06 - Model Development, Genetic Tools. Sep 04 - Aug 14 - Jul 18 - May 16 - Precision medicine. Given this, I'd much rather be able to rapidly obtain reproducible results in the mouse, and then go on and do the real experiment in humans. Focusing on genetic diversity in a mouse model of disease may be putting the cart before the horse in many cases.

Bottom line: if we had your results, we would ignore the outbred model and use the positive results in the inbred model to justify further drug development work. I'm certain most companies would do the same.

Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 19, UConn Health. Search University of Connecticut. A to Z Index. Source: Mouse Genome Informatics email list. Question We recently found a treatment that protected B6 inbred mice against hypoxia.